BOVINE CORONAVIRUS-ESCHERICHIA COLI ANTIBODY with BOVINE ORIGIN

PRODUCT DESCRIPTION:

FIRST DEFENSE^® is a capsule containing antibodies which aid in the reduction of morbidity and mortality from neonatal calf scours caused by K99+ E. coli and bovine coronavirus. Maximal protection is achieved when administered in the first 12 hours after birth and used in conjunction with good colostrum feeding and calf nutrition programs. Neutralizing antibodies against bovine coronavirus as well as antibodies specific for E. coli K99+ pilus antigens present in FIRST DEFENSE^® are prepared from hyperimmune bovine colostrum. A FIRST DEFENSE^® capsule containing dried colostral antibodies dissolves readily upon reaching the calf’s stomach to provide passive protection against intestinal infection. Specific antibodies in FIRST DEFENSE^® serve to block enterotoxigenic E. coli adherence and interfere with virus infection of intestinal epithelial cells, thereby reducing scours-related morbidity and mortality.

INDICATIONS:

FIRST DEFENSE^® is used as an aid in the reduction of morbidity and mortality from scours caused by K99+ E. coli and bovine coronavirus.

PRECAUTIONS:

FIRST DEFENSE^® capsules are supplied in individual, moisture resistant blister packs which can be stored at, or below room temperature -23°C (72°F). Product is not harmed by freezing. If frozen, allow blister package capsule to warm to room temperature before removal from blister and administration. Capsules should remain in their blister packs until administered.

DIRECTIONS:

A capsule dose of FIRST DEFENSE^® should be given to each calf within the first 12 hours after birth. If the calf is to be tube fed, it is recommended to do so prior to dosing. To administer, remove a FIRST DEFENSE^® capsule from its blister pack by tearing off the foil backing and follow the instructions recommended below:

1. Place the large end of the capsule in a dosing gun (16 mm/5/8” opening) until firmly seated. Avoid guns with undersized openings which may fracture the capsule shell or oversized openings which could allow the capsule to slip.
2. Restrain the calf. Gently pry open its mouth and place the dosing gun containing the capsule into the back of the throat. Administer the capsule as close to the esophageal opening as possible. Use caution to avoid delivery to the trachea.
3. To assist passage of the capsule down the esophagus and to stimulate a swallowing reflex, stroke the surface of the tongue or the outside of the throat. Whenever possible, bottle feed or allow the calf to suckle immediately after administering the capsule. Watch for signs of breathing difficulty after administering the capsule.
4. Dosing gun should be cleaned and dried immediately following administration of capsule to each calf